Sysmex Journal International
Evaluation of the Diagnostic Performance of the Sysmex XT-2000i Automated Hematology Analyzer in the Detection of Immature Granulocytes
A. M. CENCI＊１, M. MACONI＊２, and B. CASOLARI＊１
*1 Laboratory of Clinical Pathology
*2 Laboratory of Clinical Pathology, Azienda Ospedaliera Arcispedale Santa Maria Nuova
Immature Granulocytes ( IG ) are normally not present in peripheral blood. Their presence is an important indicator of enhanced bone marrow activation. The present study evaluated the diagnostic performance of the Sysmex XT-2000i automated hematology analyzer in the detection of myelocytes and/or metamyelocytes in patients affected by non-haematological disease, in comparison with manual microscopy review ( NCCLS H20-A ) and also in comparison with Sysmex XE-2100, used as a predicate device.
Sysmex XT-2000i shows good specificity and sensitivity in the detection of low, medium and high concentrations of immature myeloid cells. The diagnostic performance of the XT-2000i IG and LS flags is very high and comparable to the results obtained with Sysmex XE-2100.
These results suggest that Sysmex XT-2000i would be an excellent second analyser for larger laboratories concerned with harmonization of instrumentation ( in particular as a back-up for Sysmex XE-2100 ), or as a primary instrument for medium-sized routine or STAT laboratories.
Automated Hematology Analyzer, XT-2000i , Immature Granulocytes, NCCLS H20-A