Gene Measurement Technologies
We are working on technologies to enable the measurement of gene quantities inside cancer cells and the detection of circulating cancer cell-derived DNA.
Gene Measurement Technologies : OSNA™ method
In general, gene amplification (such as the RT-PCR method) reaction requires a process to prevent impurities in the sample from affecting the gene amplification reaction. Also, it takes more than one hour for the gene amplification reaction.
Sysmex has developed the one-step measurement technology for cancer cell derived biomarkers (CK19mRNA) in the lymph node by optimizing composition of the pretreatment (homogenization) liquid and the raw materials (enzymes and primers) to enable elimination of process of the nucleic acid purification.
●Plasma-Safe-SeqS Technology
Cancer patients' blood includes mutant genes which are drained from cancer tissue.
Very slight amounts of cancer-derived genes must be detected among huge amounts of normal genes in the blood in order to specify these mutations.
Next generation sequencers (NGS) are used to examine gene information, but they include a certain number of reading errors. Thus it can be difficult to distinguish an original gene mutation from a reading error of NGS when a mutation is detected.
Sysmex is developing Plasma-Safe-SeqS (PSS) as a pretreatment technology to overcome NGS problems.
PSS technology differentiates gene mutations from reading errors by tagging amplified DNA. We detect slight amounts of original gene mutation to implement a liquid biopsy, and realize personalized medicine by contributing proper diagnostics and drug administration.
