Research & Development
Technology Awards
Title of the award: | Elucidating the Mechanisms of Mitochondrial Morphological Changes Detectable by AI-Driven Flow Cytometry in Chronic Myeloid Leukemia Cells |
Winners: | Kohjin Suzuki |
Date of the award: | July 7, 2024 |
Description of the invention: |
Our collaborative research focuses on the detection of leukemia cells using "Ghost Cytometry," an artificial intelligence (AI)-driven flow cytometry, with the aim of achieving early diagnosis of chronic myeloid leukemia (CML). In this presentation, we reported that the BCR::ABL1 gene, which is responsible for CML, induces morphological changes in mitochondria, one of the intracellular organelles. Furthermore, we elucidated the molecular mechanisms underlying these changes. We demonstrated the potential of Ghost Cytometry to accurately distinguish CML cells by capturing such subtle cellular biological changes using AI. |
Note: | Collaboration with Sysmex Corporation, Juntendo University, Tokyo Medical and Dental University, and ThinkCyte K.K. |