Sysmex Journal International
2024Vol.34 No.2
RepublishedFuminori ARISAWA*1, Shinobu WAKAMOTO*1, Wataru OHASHI*1, Yuichi TONE*1,3, Kaori SHIBAGAKI*2, Hidekazu KOMAKI*2, Hideo KITAGAWA*2, Kiichiro NAMURA*2, Mitsuaki AKINO*1 and Shuichi KINO*1,4
*1 Japanese Red Cross Hokkaido Block Blood Center
*2 Japanese Red Cross Kinki Block Blood Center
*3 (Japanese Red Cross Kyushu Block Blood Center)
*4 (Japanese Red Cross Blood Service Headquarters)
The residual white blood cell count (rWBC) in blood products, the platelet count (PLT) and residual red blood cell count (rRBC) in platelet concentrate (PC), and the hemoglobin concentration (HGB) in frozen-thawed red blood cell (FTRC) solutions are each measured by different methods.
The XN-Series Automated Hematology Analyzer (Sysmex Corporation, Kobe, Japan; hereinafter XN-1000), introduced in September 2022 as a testing system for rWBCs, is equipped with a measurement mode for quality testing of blood products, Blood Bank mode (BB), which may allow multiple tests to be performed at once. The XN-1000’s BB (XN-1000/BB) can be used for quality tests other than rWBC assays. The PLT assay in PC showed good linearity at concentrations of 600 to 4,000 × 103/μL, eliminating the need to reassay high-concentration PLT samples, which is required in the conventional method. When excessive rRBC contamination is suspected in PC, specimens are examined using a blood cell counting chamber. The XN-1000/BB showed good correlation with the visual method in the rRBC range of 50 to 5,000/uL, thus eliminating the need for further specimen examination. The HGB of FTRC showed linearity over a range of 7 to 23 g/dL which correlated well with the conventional method. It was confirmed that multiple quality tests can be performed with a single XN-1000/BB. The introduction of this system is expected to reduce reagent inventory, manual testing steps, and lab costs.
XN-1000, Blood Bank mode, Hematological Examination, Blood Components
This article is translated and republished from Journal of the Society for Japanese Blood Programme,
Vol. 46, No.4: 721–730, February 2024, with the permission of the publisher.