Performance Comparison of Sysmex Hematology Analyzers XN-550 and XN-10

• Performance Comparison of Sysmex Hematology Analyzers XN-550 and XN-10

AUTHOR(S)

Ashley ORTIZ and Julie DEMARCO

Tricore Reference Laboratories

SUMMARY

Background: Sysmex XN-L series (XN-550) was introduced globally in 2015 as compact automated analyzers that are suitable for small hospitals and physician clinics. This is the first US-based evaluation on XN-550. The principles of XN-550 are based on XN series functionality, operability and clinical parameters. The footprint of XN-L series is among the smallest and is equipped with advanced testing modalities including measurement of reticulocyte indices with the RET-He test, low white blood cell (LWBC) and body fluid modes in addition to conventional hematologic parameters.

Methods: Performance of the XN-550 was compared to high throughput automated analyzer XN-10, manual differential counts and morphology review using peripheral blood samples (n=207). Analytical performance, flagging performance, and precision were evaluated. Work flow was assessed.

Results: Deming regression and correlation of CBC parameters comparing XN-550 and XN-10 showed high correlation of 28 parameters (r=0.8275 to 0.9999). Notably, all the RBC-related parameters obtained from the RET channel as well as the platelet count (PLT) had high correlation. Flagging performance also showed high correlation. Work flow study revealed a throughput of 60 samples per hour.

Conclusion: The XN-550 has shown high correlation coefficient and excellent comparative performance when compared to XN-10. Our study demonstrated that XN-550 is highly reliable and comparable to XN-10 and thus could offer opportunity especially in small hospital laboratories and physician clinics. Moreover, XN-550 can be used as a backup system if a high volume analyzer of XN-series needs maintenance as well as for emergency situations.

KEY WORDS

Hematology, Analyzer, Performance Evaluation, Flagging, Precision, Workflow, Body Fluid

NOTE(S)

This article is based on current regulatory requirements in the United States. (as of Oct. 2019)
The specifications, performances and functions described here may be different depending on the regions or the countries due to the regulatory affairs, legal matters or local guidelines. For more details, please contact your regional affiliates or distributors.