Sysmex Journal International
Reference Values for Immature Granulocytes in Healthy Blood Donors Generated on the Sysmex XE-2100 Automated Hematology Analyser
M BRUEGEL＊１, GM FIEDLER＊１, G MATTHES＊２ and J THIERY＊１
*1 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig
*2 Institute of Transfusion Medicine, University Hospital Leipzig
An increase in immature granulocytes ( IG ) in peripheral blood is of great importance for the diagnosis of hematological malignancies. Furthermore, it may indicate systemic inflammation. IGs are usually quantified by visual microscopy ; however, recent studies have evaluated automated IG count on the DIFF channel and IG detection on the IMI channel of the Sysmex XE-2100 automated hematology analyser.
The aim of the present study was to generate reference values for these parameters. Men and women showed comparable reference intervals for the IG counts; the 5th percentile was zero and the 95th percentile was 0.03 × 109/ L for both men and women. For the IG count in percent ( %IG ) the 5th percentile was zero and the 95th percentile was 0.5% for men and 0.4% for women.The count of myelocytes in the IMI channel in the study population resulted in a 5th percentile of zero and a 95th percentile of 0.03 ×109/ L for both men and women.
The clinical value of these automated measurements has to be elucidated in further clinical studies.
Immature Granulocytes, IG Count, Immature Information, IMI, Reference Intervals