Sysmex Journal International

2002Vol.12 No.1


Measuring the Biological Activity of Recombinant Human Erythropoietin (rHuEPO) by R-500, Automated Reticulocyte Analyzer, in vivo


Qingzhou-Wang*1, Wei-Wang*1, Yaqing-Cheng*1, and Wei-Chen*2

*1 National Institute for the Control of Pharmaceutical and Biological Products, China
*2 Zhixin healthcare corporation, China


Objective: Improve laboratory methods in testing biological activities of rHuEPO by using R-500, automated reticulocyte analyzer, instead of traditional microscopic counting method.

Methods: Testing 20 rHuEPO samples by two methods respectively.

Result: There was no significant difference between the two testing methods statistically.

Conclusion: R-500 automated reticulocyte analyze method can replace traditional microscopic counting method as an available laboratory evaluation in measuring the biological activities of rHuEPO.


rHuEPO, Reticulocyte, Biological Activity in Vivo, R-500, Automated Reticulocyte Analyzer

Received 16 January, 2002; Accepted 1 February, 2002