Sysmex Journal International

2002Vol.12 No.1

Original

Measuring the Biological Activity of Recombinant Human Erythropoietin (rHuEPO) by R-500, Automated Reticulocyte Analyzer, in vivo

AUTHOR(S)

Qingzhou-Wang*1, Wei-Wang*1, Yaqing-Cheng*1, and Wei-Chen*2

*1 National Institute for the Control of Pharmaceutical and Biological Products, China
*2 Zhixin healthcare corporation, China

SUMMARY

Objective: Improve laboratory methods in testing biological activities of rHuEPO by using R-500, automated reticulocyte analyzer, instead of traditional microscopic counting method.

Methods: Testing 20 rHuEPO samples by two methods respectively.

Result: There was no significant difference between the two testing methods statistically.

Conclusion: R-500 automated reticulocyte analyze method can replace traditional microscopic counting method as an available laboratory evaluation in measuring the biological activities of rHuEPO.

KEY WORDS

rHuEPO, Reticulocyte, Biological Activity in Vivo, R-500, Automated Reticulocyte Analyzer

Received 16 January, 2002; Accepted 1 February, 2002