Preliminary Data on the Feasibility of Bone Marrow Screening on the Sysmex XE-2100 Automated Hematology Analyzer

• Preliminary Data on the Feasibility of Bone Marrow Screening on the Sysmex XE-2100 Automated Hematology Analyzer

AUTHOR(S)

W. GOOSSENS, C. BRUSSELMANS and N. BOECKX

Department of Laboratory Medicine, Laboratory of Hematology, University Hospital Leuven

SUMMARY

In the present study we investigated the potential of the Sysmex XE-2100 automated hematology analyzer as a screening device for bone marrow ( BM ) aspirates. We evaluated BM cellularity, white blood cell ( WBC ) differential count, immature granulocyte ( IG ) count, nucleated red blood cell ( NRBC ) count, granulocyte/erythroid ( G/E ) － and myeloid/erythroid ( M/E ) ratio, and potential pathologyrelated scattergrams ( ‘pathology patterns’ ). Our data are derived from analyses of 160 BM samples of patients with hematological malignancies.

Our preliminary data indicate that the Sysmex XE-2100 opens new perspectives for use as a primary screening device for BM samples, particularly in cases of acute and chronic lymphocytic and myeloid leukemias, where distinct pathology-related scattergram patterns have the potential to be of diagnostic help. Software improvements are required for further progress.

KEY WORDS

Born Marrow Screening, Scattergram Patterns, Automated Hematology Analyzer, XE-2100