Sysmex Corporation (HQ: Kobe, Japan; Chairman & CEO: Hisashi Ietsugu) and Kyoto University (Sakyo-ku, Kyoto, Japan; President: Juichi Yamagiwa) announce the development of a fully automated measurement method for soluble immune checkpoint molecules (sPD-1, sPD-L1 and sCTLA-4) through joint R&D conducted since 2013 by Sysmex and Tasuku Honjo, a distinguished professor at the Kyoto University Institute for Advanced Studies. The two parties will proactively conduct clinical research using this measurement method to create new diagnostic technologies for cancer and immune disease.
Overview of the Measurement Method
Parameters | sPD-1 | sPD-L1 | sCTLA-4 |
Measurement principle | CLEIA (automatic) | ||
Detection sensitivity (pg5/mL) |
3.9 | 6.8 | 0.4 |
Dynamic Range (pg/mL) |
10.0 - 5000.0 | 25.0 - 5000.0 | 1.0 - 5000.0 |
Website of Assay Services for Research
http://lifescience.sysmex.co.jp/products/hi1000/pd-1/
Terminology
1. | Immune homeostasis: | |
Refers to the function of maintaining a steady level of immunity by enhancing immunity to protect the body from external pathogens, while suppressing it to prevent excessive immune enhancement. | ||
2. | Autoimmune diseases: | |
Immunity normally plays the role of protecting the body from incursion by foreign matter. Autoimmune diseases occurs when these immune cells mistake the body’s cells and tissues as foreign matter and attack them. Autoimmune diseases include connective tissue disease, thyroid disease, myasthenia gravis and type 1 diabetes, and so on. |
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3. | Cancer immune escape: | |
Cancer cells are known to use immune checkpoint molecules’ immunity suppressive function to avoid attack by the immune system. | ||
4. | Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma Scientific Reports 2019; vol. 9, 10144 |
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5. | pg (picogram): | |
1 pg = 1 one-trillionth of a gram | ||
About Sysmex Corporation
In line with its mission of “shaping the advancement of healthcare,” which is defined in the “Sysmex Way,” the corporate philosophy of the Sysmex Group, Sysmex works to contribute to the development of healthcare and the healthy lives of people. Sysmex provides integrated R&D, manufacturing, sales, service and support for the instruments, reagents and software needed for in vitro diagnostics of blood, urine and other samples. Sysmex provides products to healthcare institutions in more than 190 countries and regions. In recent years, Sysmex’s business has been expanding into the life science domain. The company is using proprietary technologies to create new testing and diagnostic value in the aim of realizing healthcare that is optimized for individual patients, reducing the burden on patients and helping to increase their quality of life. To learn more about Sysmex Corporation, visit https://www.sysmex.co.jp/en/ About Kyoto University Kyoto University is one of Japan and Asia's premier research institutions, founded in 1897 and responsible for producing numerous Nobel laureates and winners of other prestigious international prizes. A broad curriculum across the arts and sciences at both undergraduate and graduate levels is complemented by numerous research centers, as well as facilities and offices around Japan and the world. For more information please see: http://www.kyoto-u.ac.jp/en/ |