In 1988, we developed the R-1000, the world’s first instrument capable of automatically measuring reticulocytes, using the flow cytometry method. The XE-Series, developed in the late 1990s, used a semiconductor laser as its light source. Accordingly, the amount of data obtained through individual blood cells dramatically increased. The flow cytometry method involves using specialized reagents to stain and dilute blood cells.
These blood cells are passed through a flow cell, and irradiated by laser. After that, they can be classified by analyzing the three types of signal: forward-scattered light, side-scattered light and lateral-fluorescent light.