

| 2000 | Jan | Established the Chinese subsidiary Sysmex Shanghai Limited. in shianghai. |
| Mar | Promoted to the 1st Section of the Tokyo Stock Exchange and the Osaka Securities Exchange. | |
| Established the French subsidiary SYSMEX FRANCE S.A.R.L. (presently Sysmex France S.A.S.) | ||
| Apr | Established the Central Research Laboratories in the Techno Center(presently the Technopark). | |
| Kakogawa Factory obtained an ISO14001 certification for its global standard of environmental management. | ||
| May | Established the Taiwanese subsidiary Sysmex San Tung Co., Ltd., in Taiwan. | |
| Jul | Established the Shanghai subsidiary Sysmex Infosystems China, Ltd. |

Central Research Laboratories
| 2001 | Mar | Established an African Service Center to provide technical services in Africa. |
| Sep | Acquired in Delphic Medical Systems and changed its name into Sysmex Delphic Limited. (presently Sysmex New Zealand Limited) | |
| Released PAMIA-40i Immunoagglutination Analyzer, which reduces testing time by two-thirds through whole blood testing |
| 2002 | Mar | Established the Indonesian subsidiary PT.Sysmex Indonesia. |
| Apr | INTERNATIONAL REAGENTS CORPORATION (presently Sysmex International Reagents Co., Ltd.) became a wholly-owned subsidiary through a stock-for-stock exchange. |
| 2003 | Jun | Marged two US subsidiaries,SYSMEX CORPORATION OF AMERICA and SYSMEX INFOSYSTEMS AMERICA,INC. to establish Sysmex America, Inc. |
| Aug | Established the Chinese subsidiary Sysmex Wuxi Co.,Ltd.(the 2nd reagent factory) in Jiangsu. | |
| Dec | Consolidated SYSMEX MOLIS S.A. (presently Sysmex Belgium IT S.A.) and SYSMEX DELPHIC LIMITED(presently Sysmex New Zealand Limited),the Sysmex Group’s overseas IT enterprises,as wholly-owned subsidiaries. |
| 2004 | Apr | Acquired 50.8% of the shares in CNA CO., LTD.(presently Sysmex CNA Co., Ltd.), a medical data systems enterprise, and consolidated as a subsidiary. |
| Mar | Established the research and development bases at the Business Support Center for Biomedical Research Activities (BMA) on Port Island Second Stage, off shore from Kobe. |
| 2005 | Apr | Acquired the reagent development operations of INTERNATIONAL REAGENTS CORPORATION(presently Sysmex International Reagents Co., Ltd.)through the separation method. |
| May | Established the SolutionCenter in Nishi-ku, Kobe. | |
| Established the European subsidiary Sysmex Polsca Sp.z o.o. | ||
| Dec | Established Sysmex Women’s Track & Field Team. |

SolutionCenter
| 2006 | Jan | Released the high-performance, Compact Automated Hematology Analyzer “XS series”. |
| Established the Republic of South Africa subsidiary Sysmex South Africa(Pty)Ltd. | ||
| Jul | Established "R&D Center Europe" in Germany. | |
| Aug | Released the in vitro diagnostics industry's first coagulation analyzer with a multi-wavelength pre-analytical check, the CS-2000i. | |
| Sep | Established the European subsidiary Sysmex Digitana AG in Switzerland. | |
| Oct | Established Sysmex India Pvt. Ltd., a subsidiary company in India. | |
| Dec | Enters into agreements for joint R&D, clinical development and marketing with Affymetrix, a U.S. company that manufactures genetic analysis systems for life science research and clinical healthcare. |

XS series

CS-2000i
| 2007 | Jan | Sysmex-funded research laboratory "Sysmex-Asano Laboratory" to launch at the foundation for biomedical research and innovation. |
| Apr | Established Corporate Philosophy, the “Sysmex Way” and “Core Behaviors”. | |
| CNA CO., LTD.(presently Sysmex CNA Co.,Ltd.)became a wholly-owned subsidiary through a stock-for-stock exchange. | ||
| Established Tokyo Office and a Metropolitan Area Service Center. | ||
| Feb | Launched automated hematology analyzer XE-5000, the new model of its hematology analyzers line in Europe. | |
| May | Released the rapid respiratory infection diagnosis kit, POCTEM S Series. | |
| Sep | Established the European subsidiary Sysmex Austria GmbH.and Sysmex Slovakia s.r.o. | |
| Oct | Established the US subsidiary Sysmex Canada, Inc. | |
| Established the European subsidiary Sysmex Hungria Kft.and SYSMEX CESKA REPUBLIKA S.R.O.(presently Sysmex CZ s.r.o.) | ||
| Released HISCL-2000i, a Fully Automated Immunoassay Analyzer Enabling Highly Sensitive and High-Speed Assay |

POCTEM S Series

HISCL-2000i
| 2008 | Jan | Formed a Commercial Joint Venture with bioMérieux for the Japanese In Vitro Diagnostics Market. |
| Released the Gene Amplification Detector “RD-100i”. | ||
| Jun | Established the Dubai's subsidiary Sysmex Middle East FZ-LLC. | |
| Oct | Renewed the new corporate logo on the occasion of the 40th anniversary of the company's establishment. | |
Opened the Technopark, Sysmex's Research and Development Headquarters. Double the size of previous 'Techno Centre' facilities |
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| Dec | The Indian joint venture Sysmex India Pvt. Ltd. became a wholly-owned subsidiary. |

RD-100i
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Corporate logo

Technopark
| 2009 | Feb | Launched XT-4000i, a New Model in its XT Series of Hematology Analyzers. |
| Apr | Opened the Sysmex Kids Park, an in-house daycare center in Technopark | |
| Established the Nederlandish subsidiary Sysmex Nederland B.V. | ||
| Established the Belgian subsidiary Sysmex Belgium B.V. |

Sysmex
Kids Park