In the 1980s, instruments capable of three-part differentiation of white blood cells became common, but the market required more detailed information about white blood cell types to diagnose certain diseases. To meet these needs, we took the lead in developing the NE-Series, which is capable of simultaneous counting and five-part differentiation of white blood cells, in the late 1980s.
This detection method combined radio frequencies (RF) and direct current (DC). When blood was passed through the pore in the detection unit, changes in DC impedance indicated cell size (volume), and changes in RF impedance simultaneously allowed measurement of intracellular information. By combining these methods with the use of specialized reagents, we were able to provide highly precise data about white blood cell types.