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Nov. 29, 2016

Sysmex to Exhibit the RF-500 Flow Cytometer for the Research and Industrial Domains at the Molecular Biology Society of Japan and the Japanese Society for Immunology

  Sysmex Corporation (HQ: Kobe, Japan; Chairman and CEO: Hisashi Ietsugu) will be exhibiting, prior to sales launch, the RF-500 flow cytometer, its new product for the research and industrial domains. The instrument will be on exhibit with the Molecular Biology Society of Japan and the Japanese Society for Immunology.

  The states of individual cells and the interactions between cells have a significant impact on phenomena (such as disease states) that occur within the body. Clarifying such phenomena requires observing individual cells to determine their sizes, internal structures and other characteristics, as well as observing large numbers of cells to see the dispersion of the number of cells with individual characteristics.
  Flow cytometry (FCM) is the technology used for individually observing large numbers of cells. The instruments that use this technology for measurement are called flow cytometers.
  A flow cytometer observes each cell of a lined-up flow of by using laser light and fluorescent dyes, analyzing cell characteristics quickly and with a high level of sensitivity. Various cell measurements require monoclonal antibodies1 labeled with fluorescent dyes. Flow cytometers are used in various domains. They are used in the clinical domain for clinical tests such as those conducted in hospitals. In the research domain, they are used in basic research (such as cancer and regenerative medicine) performed by universities and companies. Flow cytometers are also used in the industrial domain, for quality control in agriculture, fishing and food production.

  Sysmex is a comprehensive manufacturer that conducts research and development, manufacturing, sales, and service and support of diagnostic instruments, reagents and software. We welcomed Sysmex Partec, a pioneer in FCM technology that possesses many years of accumulated expertise, into the Group in September 2013. Together, we have engaged in the development of new flow cytometers for the clinical, research and industrial domains.
  The RF-500 flow cytometer offers quality levels equivalent to those of clinical diagnostic instruments, which realize low cost and space-saving design. We plan to launch this flow cytometer in May 2017. At the same time, we plan to introduce approximately 1,400 monoclonal antibodies, centering on human CD markers2.
  Prior to launch, we will be exhibiting the RF-500 flow cytometer with the Molecular Biology Society of Japan and the Japanese Society for Immunology.

  Going forward, Sysmex plans to leverage the academic information that Sysmex Partec has accumulated in Europe, and to enhance our product lineup, thereby establishing a flow cytometer business in the research and industrial domains.  


Overview of Exhibitions

  The 39th Annual Meeting of the Molecular Biology Society of Japan

 

Dates:

November 30 (Wednesday) to December 2 (Friday), 2016

  Location: Pacifico Yokohama
  Booth number: 128
 
  The 45th Annual Meeting of the Japanese Society for Immunology
 

Dates:

December 5 (Monday) to December 7 (Wednesday), 2016

  Location: Okinawa Convention Center, Laguna Garden Hotel
  Booth number: 4
 


New Product Features

  - Can be used with various applications, such as cellular and microbial analysis 
  -
 
Stable optics and flow design, eliminating the need for troublesome daily sensitivity adjustment and fluorescence compensation
  -

 
Due to the syringe sample measurement3, achieves highly precise measurement of the absolute number of particles without using reference beads4
  -
 
Contains extensive quality control program and network connectivity/external output programs
  - Software available in Japanese, English and Chinese
  -
 
In addition to optional auto-sampler5 and autogate function6, contains specialized applications that enable hemolysis and semi-automated dilution
 

Terminology

 

1

Monoclonal antibody:
A monoclonal antibody is an antibody molecule obtained from a clone derived from a single antibody production cell. Typical polyclonal antibodies are prepared from the blood serum of animals with antigen immunity, so include a mixture of various types of antibody molecule, but a monoclonal antibody has only one type of molecule.
A flow cytometer analyzes human blood by combining a human CD marker with a monoclonal antibody to analyze a specific cell population that contributes to immunity, allowing the human immune state to be determined.
 

  2 Human CD marker:
This is an international classification of the molecules (surface antigens) present mainly on the cell surfaces of human leukocytes. Glycoproteins and various other molecules are expressed on the surface of leukocytes and other cells, and determining the differences among these molecules allows for the identification of different cells. 
 
  3 Syringe sample measurement:
This is one method of determining sample volume, by aspirating a measured sample into a syringe.
 
  4



5
Reference beads:
Used as a reference to accurately determine the number of cells, these beads are used to clarify pre-concentration.

Auto-sampler:
    An instrument for automatically and continuously processing and analyzing a large number of samples.
     
  6 Autogate function:
A flow cytometer function that allows for the automated analysis of a desired cell population.

*Information contained in the press release is current as of the date of the announcement,
but may be subject to change without prior notice.

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